Executive Director, Oncology Early Clinical Development Lead - Heme
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Executive Director, Oncology Early Clinical Development Lead - Heme
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Executive Director, Oncology Early Clinical Development Lead - Heme
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Join to apply for the Executive Director, Oncology Early Clinical Development Lead - Heme role at GSK
Site Name: USA - Pennsylvania - Upper Providence, Switzerland - Zug, UK - Hertfordshire - Stevenage, UK – London – New Oxford Street, USA - Massachusetts - Waltham
Posted Date: Aug 5 2025
Are you a physician leader excited by leading early-phase oncology clinical development and shaping the translational strategy for cutting-edge Hematology therapies? If so, the Executive Director, Oncology Early Clinical Development Lead may be an ideal opportunity to explore.
GSK ONCOLOGY
GSK's ambition is to help increase overall quality of life, maximize survival and change the course of disease, expanding from our current focus on blood and women's cancers into lung and gastrointestinal cancers, as well as other solid tumors.
Accelerated research areas including tumor-cell targeting therapies and next generation immuno-oncology agents, drawing internal capabilities, expertise in human genetics and the science of the immune system, as well as that of GSK's partners.
Multiple investigational medicines in GSK's oncology pipeline that have the potential to make a meaningful difference for patients with cancer, and we continue to grow the pipeline through targeted business development.
GSK Oncology Clinical Development seeks an Executive Director, Oncology Early Clinical Development Lead to drive the successful translation of therapies from preclinical research to clinical development. Reporting into the VP, Oncology Clinical Development – Heme, this role involves leading a team of Medical Directors and Clinical Scientists to design and execute early-phase studies while enhancing collaboration between Clinical Development and Preclinical/Discovery teams to optimize translational research strategies and advance GSK’s Oncology portfolio.
Please note: This position requires an on-site office-based presence 2 to 3 days a week in the US (Upper Providence, PA. or Waltham. MA.); UK (London or Stevenage); or Switzerland (Zug).
Key responsibilities:
Clinical Study Design & Execution:
- Develop clinical development plans (CDPs) for a portfolio of Phase I/II trials, including first-in-human, dose-escalation, and POC studies.
- Accountable for driving the end-to-end clinical development strategy and ensuring alignment to target medicine profiles (TMPs) and integrated evidence plans (IEPs) across all phases of development.
- Lead clinical strategy discussions at regulatory interactions and accountable for drafting clinical components of regulatory submissions (e.g., IND, NDA, BLA).
- Serve as a core member of the Medicine Development Team (MDT)/Early Development Team (EDT), providing single clinical development accountability at the program level.
- Ensure compliance with regulatory requirements, GCP guidelines, and GSK policies.
- Collaborate with teams across Oncology Research, Preclinical, Translational Science, AI/ML, and Clinical Pharmacology to develop and execute translational research strategies.
- Partner with Oncology Tumor Teams (OTTs) to advance translational strategies across assets and drive innovation in study designs.
- Interpret clinical and translational data to guide regulatory documents, safety analyses, and health authority responses.
- Author and/or review clinical data publications, abstracts, and presentations.
- Lead preparation of clinical sections for regulatory filings and governance discussions.
- As a therapy area subject matter expert, be accountable for integrating inputs from cross-disciplinary teams to ensure alignment on translational research initiatives.
- Build and maintain relationships with key external experts, academic collaborators, and research organizations, including the Oncology Translational Network.
- Serve as program medical expert for internal and external stakeholders.
- Lead, mentor, and coach a team of Oncology Early Clinical Development Medical Directors and Clinical Scientists.
- Drive cross-functional integration, alignment and collaboration to execute CDPs and translational strategies effectively.
- Foster a bold, swift, and integrity-driven culture within the team while contributing to standardized processes in Oncology Clinical Development.
Basic Qualifications:
- Medical degree and Oncology board certification/eligibility/registration
- Clinical and research experience in Hematology.
- Strong physician scientist experience in the pharmaceutical industry or robust academic setting in the field of hematology/oncology with a focus on early phase clinical trials and translational research in hematology
- Experience designing and executing early phase clinical studies, including FTIH and POC trials
- Experience in hematology treatment guidelines, therapeutic competitive landscape, clinical development process and drug approval process in major regions
- Experience developing and driving translational strategy: biomarker, companion diagnostic, PK/ PD modeling and simulation
- Experience managing direct reports and leading matrix teams
- Global regulatory experience
- Medical degree and Hematology board certification/eligibility/registration
- PhD in addition to medical degree and Oncology/Hematology board certification/eligibility/registration
- Experience in multiple myeloma, myeloproliferative disease spectrum, AML, MDS and MF.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/
Seniority level
Seniority level
Not Applicable
Employment type
Employment type
Full-time
Job function
Job function
Business Development and SalesIndustries
Pharmaceutical Manufacturing
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#J-18808-Ljbffr- Location:
- Stevenage, England, United Kingdom
- Salary:
- £100,000 - £125,000
- Job Type:
- FullTime
- Category:
- Bio & Pharmacology & Health
