Director Translational & Clinical Genetics

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Overview Director, Translational & Clinical Genetics – GSK We are seeking a highly experienced, motivated and innovative individual to join the Translational & Clinical Genetics team within GSK Human Genetics and Genomics. The successful candidate will provide strategic leadership and undertake hands-on analyses to identify, develop and deliver a portfolio of translational data‑driven activities to impact the GSK portfolio. You will have strong expertise in genetics, with emphasis on causal inference approaches, and experience integrating genetics with genomics (especially proteomics) and clinical phenotypic data. Your work will inform target discovery, biomarker discovery, disease and mechanistic understanding, indication and patient subgroup selection, and parsing treatment response using precision medicine approaches.
You will lead a team of direct reports in a multidisciplinary, collaborative environment, interacting with GSK scientists and external collaborators to advance drug discovery and clinical development. You will identify, establish and oversee collaborations with external institutions aligned with strategic priorities and be supported in developing your scientific leadership through impactful work, visibility to stakeholders, and publication activity. Key Responsibilities
Utilize deep expertise in statistical genetics and the integration of genetics with genomic (including proteomics) and clinical phenotypic data to generate at-scale insights and address translational scientific questions. Provide strategic leadership and hands-on analytical work to identify, develop, and deliver programs to impact the GSK drug development pipeline. Lead cross-functional project teams, with emphasis on respiratory, hepatology, neurodegeneration, immunology and/or renal disease. Identify, set up and oversee external scientific collaborations. Communicate analysis findings clearly to project teams within and outside the Human Genetics & Genomics organization. Deliver personal and team objectives with strong statistical, analytic and translational context understanding. Stay informed about emerging technologies and methodologies in translational genetics, with evaluation and implementation opportunities for the organization. Lead and foster a culture of innovation, collaboration, and continuous professional learning within the team.
Basic Qualifications
PhD or equivalent advanced degree in a relevant scientific discipline (e.g., statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics or machine learning) with a record of impactful scientific publications and/or presentations. Extensive experience in genetics and analyses that integrate genetics, genomics (particularly proteomics) and/or clinical phenotypic data to address translational questions in drug discovery and development. Expertise and leadership in genetic causal inference approaches (Mendelian randomization) with understanding of emerging methodologies. Ability to develop and implement new methodologies to integrate genetics and genomics for translational questions in drug discovery and development. Demonstrated ability to understand key scientific questions and develop innovative analytical solutions to impact the drug discovery pipeline. Strong proficiency in at least one of R and Python, with reproducible and scalable code aligned to FAIR principles. Experience of line management and supporting professional development of team members. Demonstrated experience communicating complex scientific concepts to diverse audiences.
Preferred Qualifications
Excellent collaboration and partnership skills to work effectively with internal stakeholders across functions. Experience setting up and overseeing external collaborations. Experience working in different trusted research environments (TREs). Ability to work independently and in multidisciplinary teams to meet project timelines. Familiarity with the stages of drug discovery and development.
Why GSK? GSK is a global biopharma company focused on uniting science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade and focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases. We are committed to an agile working culture and to creating an environment where our people can thrive. We are an Equal Opportunity Employer and do not discriminate based on race, color, religion, sex, pregnancy, gender identity, sexual orientation, parental status, national origin, age, disability, genetic information, or military service. If you require adjustments to the process, contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391. Additional information We encourage you to discuss flexibility with our hiring team. Please note that referrals from employment businesses/agencies are not accepted for vacancies on this site. Any candidate expenses processed for US Healthcare Professional compliance will be reported as required by law. #J-18808-Ljbffr
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Location:
Stevenage, England, United Kingdom
Job Type:
FullTime

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